Advantages of jet mill in medicinal grinding

With the rapid economic development, higher requirements are put forward for the fineness and purity of various powders (including pharmaceutical powders) and their grinding equipment; ultra-fine grinding is very important for medicines and can affect its efficacy. And absorption in the body; the current market demand for micronized solid drugs is increasing year by year. At present, a jet mill is usually used for ultrafine grinding of drugs.

Micropowder crystallization is obtained by controlling the crystallization process conditions to obtain ultrafine particle crystals, which are then filtered, scrubbed, drained, and dried. Micropowder crystallization is obtained by ultrafine grinding of crystal particles. The defects of micro-powder crystallization are that it is difficult to filter, wash, drain, and dry, and it is easy to cause crystal leakage during the filtering and washing process, resulting in low yield and daily output, and the final product has low purity, many impurities, and adverse drug reactions. It is aggravated, so it is generally less used in production. At present, the ultra-fine grinding process is more widely used.

The airflow grinder accelerates the compressed air or inert gas through the nozzle, and uses the energy of high-speed elastic fluid (300~500m/s) or superheated steam (300~400℃) to make particles between particles, gas and particles, and particles With the wall and other parts, there are fierce impacts, shears, collisions, frictions and other effects. At the same time, under the effect of the centrifugal force of the airflow or the combined effect of the classifier, the coarse and fine particles are classified to achieve ultra-fine grinding. . The jet mill is a common preparation method for pharmaceutical powder, and is suitable for the grinding of antibiotics, enzymes, low melting point and other heat-sensitive drugs.

The advantages of jet mills in medicine are as follows:

• The range of particle size distribution is narrow, and the average particle size is fine;
• Good powder appearance and high product purity;
• Suitable for low melting point and heat sensitive drugs;
• Good airtightness and no pollution;
• Easy to operate;
• Grinding-mixing-drying on-line operation.