Application prospect of powder modification of traditional Chinese medicine
The purpose of modifying traditional Chinese medicine powder is to ensure the dispersion uniformity of the material, design the appearance and smell of the powder according to the needs, prevent the loss of active ingredients, improve the dissolution rate of insoluble ingredients, reduce the hygroscopicity of the powder, and improve the powder. liquidity, etc.
1. The basic idea of traditional Chinese medicine powder modification
The modification of traditional Chinese medicine powder is affected by many factors, such as the properties of raw material powder, modifier and formula, modification process, modification equipment, etc. According to the factors affecting the modification of traditional Chinese medicine powder, the basic idea of traditional Chinese medicine powder modification is as follows:
(1) According to the properties of the raw material powder (specific surface area, particle size and distribution, specific surface energy, surface physical and chemical properties, agglomeration, etc.), select the appropriate modifier formula (species, dosage and usage).
(2) According to the properties of the raw material powder and the determined modifier formula, select the Chinese medicine powder modification process that meets the application conditions. The basic principle for selecting the modification process of traditional Chinese medicine powder is that the modifier has good dispersibility, which can realize the uniform dispersion of the modifier in the powder particles. At the same time, the modification process is required to be simple, the parameters are controllable, and the product quality is stable. Low energy consumption and little pollution.
(3) When the formulation and process of the modifier are determined, it is particularly critical to select the appropriate modification equipment. The selection of high-performance modification equipment can make the dispersion of the powder and the modifier good, and the contact or interaction opportunities between the powder and the modifier are equal; the modification conditions of the powder are controllable, and the energy consumption and wear per unit product are less. No dust pollution, stable operation, etc.
(4) Establish a complete set of characterization methods for modified particles of traditional Chinese medicine powder.
2. The application prospect of powder modification of traditional Chinese medicine
In traditional Chinese medicine preparations, solid preparations account for 70% to 80%, and the dosage forms mainly include powders, granules, capsules, tablets, suspensions, etc. In view of the special properties of traditional Chinese medicine powder itself, it has been found from previous research and practice that modification of traditional Chinese medicine powder can enhance the application value of traditional Chinese medicine powder to a certain extent.
In the past 20 years, with the development of science, excellent pharmaceutical excipients and high-efficiency rotary tablet presses that can be used for direct powder compression have been successfully developed, which has promoted the development of direct powder compression. In some countries, more than 60% of varieties use powder However, traditional Chinese medicine powder has problems such as easy moisture absorption, high viscosity, and poor fluidity. The production of Chinese medicine tablet varieties is still dominated by wet granulation and tablet compression, and the utilization rate of powder direct compression technology is extremely low.
The modification of traditional Chinese medicine powder can effectively improve the hygroscopicity and fluidity of traditional Chinese medicine powder, and provide more space for direct compression of traditional Chinese medicine powder. With the gradual strengthening of the understanding of traditional Chinese medicine powder modification technology, the continuous improvement of research on excellent surface modifiers and high-performance modification equipment, the application prospect of traditional Chinese medicine powder modification technology in the field of traditional Chinese medicine is broader.