![\"\"](\"https:\/\/www.alpapowder.com\/wp-content\/uploads\/2021\/09\/Processflow-en.jpg\")
<\/p>\nSo\u011fuk alg\u0131nl\u0131\u011f\u0131n\u0131z, ate\u015finiz veya ishaliniz varsa ne yapmal\u0131s\u0131n\u0131z?<\/p>\n
Tabii ki ila\u00e7 almal\u0131s\u0131n!<\/p>\n
\u0130nsanlar\u0131n sa\u011fl\u0131kl\u0131 ya\u015fam\u0131 t\u0131ptan ayr\u0131lamaz. Yayg\u0131n ila\u00e7 t\u00fcrleri aras\u0131nda haplar, gran\u00fcller vb. bulunur. Bunlar\u0131n t\u00fcm\u00fc toz haline getirildikten sonra ham maddelerden yap\u0131l\u0131r!<\/p>\n
\u0130la\u00e7 ve pudra aras\u0131ndaki ayr\u0131lmaz ili\u015fkiye bir g\u00f6z atal\u0131m…<\/p>\n
Farmas\u00f6tik \u00fcr\u00fcnlerde, kat\u0131 farmas\u00f6tik preparasyonlar yakla\u015f\u0131k %70 ila %80’dir. Kat\u0131 ila\u00e7lar\u0131 i\u00e7eren dozaj formlar\u0131 aras\u0131nda tozlar, gran\u00fcller, kaps\u00fcller, tabletler, toz enjeksiyonlar\u0131 ve s\u00fcspansiyonlar bulunur.<\/p>\n
Farmas\u00f6tik kat\u0131 dozaj formlar\u0131n\u0131n haz\u0131rlanma s\u00fcreci a\u015fa\u011f\u0131daki gibidir:<\/p>\n
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Kat\u0131 dozaj formu haz\u0131rlama<\/strong><\/p>\n K\u0131rma: bilyal\u0131 de\u011firmen, darbeli de\u011firmen, titre\u015fimli de\u011firmen, jet de\u011firmen vb. Kar\u0131\u015ft\u0131rma: Tekneli kar\u0131\u015ft\u0131r\u0131c\u0131, koni kar\u0131\u015ft\u0131r\u0131c\u0131, \u00fc\u00e7 boyutlu hareketli kar\u0131\u015ft\u0131r\u0131c\u0131, V tipi kar\u0131\u015ft\u0131r\u0131c\u0131 vb.<\/p>\n Gran\u00fclasyon: ak\u0131\u015fkanla\u015ft\u0131r\u0131lm\u0131\u015f gran\u00fclat\u00f6r, kar\u0131\u015ft\u0131rma gran\u00fclat\u00f6r\u00fc, santrif\u00fcjl\u00fc gran\u00fclat\u00f6r, ekstr\u00fczyon gran\u00fclat\u00f6r\u00fc vb.<\/p>\n Tabletleme: tek z\u0131mbal\u0131 tablet makinesi, d\u00f6ner \u00e7oklu z\u0131mbal\u0131 tablet makinesi, y\u00fcksek h\u0131zl\u0131 tablet presi vb.<\/p>\n Kurutma: sprey kurutucu, gran\u00fcl kurutucu, i\u00e7i bo\u015f k\u00fcrek kurutucu, ak\u0131\u015fkan yatakl\u0131 kurutucu vb.<\/p>\n Alg\u0131lama: lazer par\u00e7ac\u0131k boyutu analiz\u00f6r\u00fc, yo\u011funluk \u00f6l\u00e7er, y\u00fczey alan\u0131 ve g\u00f6zenek boyutu da\u011f\u0131t\u0131m \u00f6l\u00e7er, toz reometresi vb.<\/p>\n <\/p>\n Tozun \u00f6zelliklerini geli\u015ftirmek ve \u00fcr\u00fcn kalitesi ve toz operasyonu gereksinimlerini kar\u015f\u0131lamak i\u00e7in \u00e7o\u011fu kat\u0131 dozaj formunun farkl\u0131 gereksinimlere g\u00f6re i\u015flenmesi gerekir.<\/p>\n D\u00fc\u015f\u00fck partik\u00fcl yo\u011funlu\u011fu, y\u00fcksek g\u00f6zeneklilik ve d\u00fc\u015f\u00fck mukavemet ile tabletleme i\u00e7in uygundur.<\/p>\n Kompakt par\u00e7ac\u0131klar ve y\u00fcksek mukavemet ile kaps\u00fclleme i\u00e7in uygundur.<\/p>\n Kaps\u00fclleme ve kaplama i\u00e7in uygundur, par\u00e7ac\u0131klar yuvarlak, yo\u011fun ve homojendir.<\/p>\n tozun do\u011fas\u0131<\/strong><\/p>\n \u0130lk \u00f6zellik, \u015fekil, boyut, y\u00fczey alan\u0131, g\u00f6zeneklilik vb. gibi tek bir par\u00e7ac\u0131\u011f\u0131n \u00f6zelli\u011fidir. \u0130kinci \u00f6zellik, ak\u0131\u015fkanl\u0131k, doldurma \u00f6zelli\u011fi, s\u0131k\u0131\u015ft\u0131rma kal\u0131plama \u00f6zelli\u011fi vb. gibi toz agrega \u00f6zellikleridir.<\/p>\n Kat\u0131 farmas\u00f6tik \u00fcr\u00fcnler genellikle birden fazla bile\u015fenle kar\u0131\u015ft\u0131r\u0131l\u0131r. Form\u00fclasyondaki ila\u00e7 i\u00e7eri\u011finin homojenli\u011fini sa\u011flamak i\u00e7in, kar\u0131\u015ft\u0131rmadan \u00f6nce her bir bile\u015fenin belirli bir par\u00e7ac\u0131k boyutuna sahip bir toz olu\u015fturacak \u015fekilde ezilmesi ve elenmesi gerekir.<\/p>\n Toz a\u00e7\u0131s\u0131ndan bak\u0131ld\u0131\u011f\u0131nda, kar\u0131\u015ft\u0131rman\u0131n homojenli\u011fini etkileyen fakt\u00f6rler aras\u0131nda par\u00e7ac\u0131k boyutu, par\u00e7ac\u0131k boyutu fark\u0131 ve bile\u015fenler aras\u0131ndaki yo\u011funluk fark\u0131, par\u00e7ac\u0131k morfolojisi ve y\u00fczey durumu, statik elektrik ve y\u00fczey enerjisi yer al\u0131r.<\/p>\n Tozun ak\u0131\u015fkanl\u0131\u011f\u0131, par\u00e7ac\u0131k boyutu, par\u00e7ac\u0131k boyutu da\u011f\u0131l\u0131m\u0131, par\u00e7ac\u0131k morfolojisi, y\u00fczey durumu ve y\u0131\u011f\u0131n yo\u011funlu\u011fu ile ilgilidir. Durma a\u00e7\u0131s\u0131 \u03b1<30\u00b0 oldu\u011funda ak\u0131\u015fkanl\u0131k iyidir ve \u03b1>45\u00b0 oldu\u011funda ak\u0131\u015fkanl\u0131k zay\u0131ft\u0131r. Ger\u00e7ek \u00fcretimde, \u03b1<40\u00b0 b\u00f6l\u00fcnm\u00fc\u015f dozlar\u0131n \u00fcretim gereksinimlerini kar\u015f\u0131layabilir.<\/p>\n Toz par\u00e7ac\u0131klar\u0131n\u0131n boyutu, \u015fekli, par\u00e7ac\u0131k boyutu da\u011f\u0131l\u0131m\u0131, y\u0131\u011f\u0131n yo\u011funlu\u011fu ve g\u00f6zeneklili\u011fi, doldurma \u00f6zelliklerini sezgisel olarak yans\u0131tabilir.<\/p>\n Tozun radyal k\u0131rma kuvveti – sertlik ve birim alan ba\u015f\u0131na k\u0131rma kuvveti – \u00e7ekme mukavemeti \u00f6l\u00e7\u00fcl\u00fcr ve tozun bas\u0131n\u00e7 alt\u0131nda hacmi azaltma ve s\u0131k\u0131 bir \u015fekilde bir araya getirilerek belirli bir \u015fekil olu\u015fturma yetene\u011fi elde edilir.<\/p>\n Kat\u0131 farmas\u00f6tik m\u00fcstahzarlar\u0131n s\u00fcreci, par\u00e7alanmak, ilac\u0131 salmak ve insan v\u00fccudu taraf\u0131ndan emilmek; par\u00e7alanmay\u0131 te\u015fvik etmek i\u00e7in g\u00f6zeneklili\u011fi art\u0131r\u0131n, \u00e7\u00f6z\u00fcnmeyi art\u0131rmak i\u00e7in par\u00e7ac\u0131k boyutunu azalt\u0131n ve etkinli\u011fi art\u0131rmak i\u00e7in par\u00e7ac\u0131k boyutunu azalt\u0131n.<\/p>\n Par\u00e7ac\u0131k boyutu ne kadar k\u00fc\u00e7\u00fckse, biyoyararlan\u0131m o kadar b\u00fcy\u00fck olur; spesifik y\u00fczey alan\u0131 ne kadar b\u00fcy\u00fckse, biyoyararlan\u0131m da o kadar fazlad\u0131r; partik\u00fcl boyutu ne kadar k\u00fc\u00e7\u00fckse, biyoyararlan\u0131m o kadar b\u00fcy\u00fck olur.<\/p>\n Farmas\u00f6tik m\u00fcstahzarlar\u0131n kalitesini sa\u011flay\u0131n: \u00e7\u00f6z\u00fcnme, par\u00e7alanma, stabilite, g\u00f6r\u00fcn\u00fcm, aktif maddelerin tekd\u00fczeli\u011fi, mukavemet vb.<\/p>\n \u00dcretim s\u00fcrecinin sorunsuz ilerlemesini sa\u011flamak i\u00e7in: ak\u0131\u015fkanl\u0131k, doldurma, s\u0131k\u0131\u015ft\u0131rma kal\u0131plama, yap\u0131\u015ft\u0131rma, itme vb.<\/p>\n Kontrol parametreleri: par\u00e7ac\u0131k boyutu, par\u00e7ac\u0131k boyutu da\u011f\u0131l\u0131m\u0131, ak\u0131\u015fkanl\u0131k, doldurma, nem i\u00e7eri\u011fi, \u00fcst ve alt delme bas\u0131nc\u0131, kal\u0131p duvar\u0131ndaki art\u0131k bas\u0131n\u00e7 vb. ve son olarak nitelikli bir \u00fcr\u00fcn.<\/p>\n \u0130la\u00e7 kontaminasyonunu, \u00e7apraz kontaminasyonu ve kar\u0131\u015f\u0131kl\u0131\u011f\u0131 \u00f6nlemek i\u00e7in otomatik, s\u00fcrekli ve modern \u00fcretimi te\u015fvik edin.<\/p>\n \u00c7in t\u0131bb\u0131n\u0131n \u00fcretiminde ve uygulamas\u0131nda ultra ince toz haline getirme teknolojisinin avantajlar\u0131 aras\u0131nda \u015funlar yer al\u0131r: h\u00fccre duvar\u0131n\u0131n k\u0131r\u0131lmas\u0131, aktif bile\u015fenlerin \u00e7\u00f6z\u00fcnme h\u0131z\u0131n\u0131n artt\u0131r\u0131lmas\u0131; \u00c7in t\u0131bbi kaynaklar\u0131n\u0131n etkin bir \u015fekilde korunmas\u0131, t\u0131bbi malzemelerin kullan\u0131m\u0131n\u0131n iyile\u015ftirilmesi; ila\u00e7 emilimini te\u015fvik etmek ve etkinli\u011fi artt\u0131rmak; g\u00fcvenli ve hijyenik ve klinik uygulama i\u00e7in uygun.<\/p>\n Nanoteknolojinin farmas\u00f6tik uygulamalardaki avantajlar\u0131 \u015funlar\u0131 i\u00e7erir: ila\u00e7lar\u0131n kan-beyin bariyeri yoluyla merkezi sinir sistemi \u00fczerinde hareket etmesini sa\u011flamak, preparat\u0131n emilimini artt\u0131rmak i\u00e7in epidermise n\u00fcfuz etmek ve ilac\u0131n hedefleme etkisini artt\u0131rmak.<\/p>\n Toz ve ila\u00e7 yak\u0131ndan ili\u015fkilidir. \u0130la\u00e7 end\u00fcstrisinde GMP standardizasyonunun te\u015fvik edilmesi ve uygulanmas\u0131yla birlikte, toz teknolojisi ila\u00e7 end\u00fcstrisindeki insanlardan giderek daha fazla ilgi g\u00f6rd\u00fc ve daha y\u00fcksek verimli ila\u00e7lar\u0131n ara\u015ft\u0131r\u0131lmas\u0131 i\u00e7in yeni geli\u015ftirme yollar\u0131 sa\u011flad\u0131; Ayn\u0131 zamanda, ila\u00e7 end\u00fcstrisi Geli\u015fmeye devam ediyor, ayr\u0131ca toz teknolojisi ve ekipman\u0131 konusunda daha y\u00fcksek gereksinimler ortaya koyuyor. \u0130ki end\u00fcstri, kar\u015f\u0131l\u0131kl\u0131 yarar ve kazan-kazan i\u00e7in birbirini tamamlar!<\/p>\n [Bilgi Pop\u00fclerle\u015ftirme] Hangi mineral ila\u00e7lar\u0131n mevcut oldu\u011funu biliyor musunuz?<\/strong><\/p>\n <\/p>\n \u0130nsanlar\u0131n sa\u011fl\u0131kl\u0131 ya\u015fam\u0131 t\u0131ptan ayr\u0131lamaz. Yayg\u0131n ila\u00e7 t\u00fcrleri aras\u0131nda haplar, gran\u00fcller vb. bulunur. Bunlar\u0131n t\u00fcm\u00fc toz haline getirildikten sonra ham maddelerden yap\u0131l\u0131r!<\/p>\n","protected":false},"author":6,"featured_media":110939,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[830],"tags":[],"class_list":["post-110962","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-industry-news"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.alpapowder.com\/tr\/wp-json\/wp\/v2\/posts\/110962"}],"collection":[{"href":"https:\/\/www.alpapowder.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.alpapowder.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.alpapowder.com\/tr\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.alpapowder.com\/tr\/wp-json\/wp\/v2\/comments?post=110962"}],"version-history":[{"count":0,"href":"https:\/\/www.alpapowder.com\/tr\/wp-json\/wp\/v2\/posts\/110962\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.alpapowder.com\/tr\/wp-json\/wp\/v2\/media\/110939"}],"wp:attachment":[{"href":"https:\/\/www.alpapowder.com\/tr\/wp-json\/wp\/v2\/media?parent=110962"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.alpapowder.com\/tr\/wp-json\/wp\/v2\/categories?post=110962"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.alpapowder.com\/tr\/wp-json\/wp\/v2\/tags?post=110962"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\nEleme: d\u00f6ner titre\u015fimli elek, numune elek, siklon ay\u0131r\u0131c\u0131, vb.<\/p>\nToz i\u015fleme s\u00fcreci farkl\u0131d\u0131r, par\u00e7ac\u0131klar\u0131n toz \u00f6zellikleri de \u00e7ok farkl\u0131d\u0131r!<\/h4>\n
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Toz \u00f6zelliklerinin farmas\u00f6tik m\u00fcstahzarlar\u0131n prosesi ve kalitesi \u00fczerindeki etkileri nelerdir?<\/h4>\n
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Farmas\u00f6tik m\u00fcstahzarlarda toz teknolojisinin uygulamalar\u0131 nelerdir?<\/h4>\n
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Toz + ila\u00e7 birbirini tamaml\u0131yor ve beklentiler umut verici!<\/h4>\n
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\n \u00dcr\u00fcn ad\u0131<\/td>\n ana malzeme<\/td>\n Efekt<\/td>\n<\/tr>\n \n Al\u00e7\u0131<\/td>\n CaSO4<\/sub>+2H2<\/sub>O<\/td>\n Is\u0131y\u0131 uzakla\u015ft\u0131rmak, ate\u015fi azaltmak, sinirlili\u011fi gidermek ve susuzlu\u011fu gidermek i\u00e7in<\/td>\n<\/tr>\n \n \u015fap<\/td>\n KAI(SO4<\/sub>)2<\/sub>\u00b712H2<\/sub>O<\/td>\n Balgam s\u00f6kt\u00fcr\u00fcc\u00fc ve ka\u015f\u0131nt\u0131y\u0131 giderir, ishali detoksifiye eder ve rahatlat\u0131r<\/td>\n<\/tr>\n \n Realgar<\/td>\n As2<\/sub>S3<\/sub><\/td>\n Detoksifikasyon, insektisit, balgam s\u00f6kt\u00fcr\u00fcc\u00fc ve s\u0131tma eliminasyonu<\/td>\n<\/tr>\n \n okra<\/td>\n Fe2<\/sub>O3<\/sub><\/td>\n Karaci\u011feri sakinle\u015ftirmek ve yang’\u0131 bast\u0131rmak, olumsuz etkileri ortadan kald\u0131rmak ve kanamay\u0131 durdurmak i\u00e7in<\/td>\n<\/tr>\n \n zencefil<\/td>\n HgS<\/td>\n Kalbi temizleyin, sinirleri sakinle\u015ftirin, sinirleri yat\u0131\u015ft\u0131r\u0131n ve detoks yap\u0131n<\/td>\n<\/tr>\n \n Ametist<\/td>\n CaF2<\/sub><\/td>\n Zihni sakinle\u015ftir, ci\u011ferleri \u0131s\u0131t ve saray\u0131 \u0131s\u0131t<\/td>\n<\/tr>\n \n M\u0131knat\u0131s<\/td>\n Fe3<\/sub>O4<\/sub><\/td>\n Kulaklar\u0131 ve g\u00f6r\u00fc\u015f\u00fc temizleyin, nefes al\u0131n ve ast\u0131m\u0131 rahatlat\u0131n<\/td>\n<\/tr>\n \n Kalamin<\/td>\n ZnCO3<\/sub><\/td>\n Detoksifiye edin, g\u00f6r\u00fc\u015f\u00fc iyile\u015ftirin, ka\u015f\u0131nt\u0131y\u0131 ve a\u011fr\u0131l\u0131 yaralar\u0131 rahatlat\u0131n<\/td>\n<\/tr>\n \n Talk<\/td>\n Mg3<\/sub>(Si4<\/sub>O10<\/sub>)(OH)<\/td>\n Di\u00fcrez, nemi ve yaralar\u0131 giderir<\/td>\n<\/tr>\n \n Do\u011fal bak\u0131r<\/td>\n FeS2<\/sub><\/td>\n Kan staz\u0131n\u0131 da\u011f\u0131tmak ve kemikleri d\u00fczeltmek, kan dola\u015f\u0131m\u0131n\u0131 te\u015fvik etmek ve a\u011fr\u0131y\u0131 gidermek<\/td>\n<\/tr>\n \n Glauber tuzu<\/td>\n NsSO4<\/sub>\u00b710H2<\/sub>O<\/td>\n Is\u0131y\u0131 rahatlat\u0131n ve kab\u0131zl\u0131\u011f\u0131 giderin, ate\u015fi temizleyin ve \u015fi\u015fmeyi azalt\u0131n<\/td>\n<\/tr>\n \n Xuanming tozu<\/td>\n Na2<\/sub>SO4<\/sub><\/td>\n Kurulu\u011fu nemlendirin, s\u0131k\u0131l\u0131\u011f\u0131 yumu\u015fat\u0131n, \u0131s\u0131y\u0131 azalt\u0131n ve m\u00fcshil<\/td>\n<\/tr>\n \n K\u00fck\u00fcrt<\/td>\n Mineral<\/a> kalkojenit do\u011fal k\u00fck\u00fcrt<\/td>\n Yaralar, yang ve m\u00fcshillerin b\u00f6cek \u00f6ld\u00fcr\u00fcc\u00fc tedavisi<\/td>\n<\/tr>\n \n k\u0131rm\u0131z\u0131 ta\u015f ya\u011f<\/td>\n AI(Si4<\/sub>O10<\/sub>)(OH)8<\/sub>\u00b74H2<\/sub>O<\/td>\n Kanamay\u0131 durdurmak, kaslar\u0131 b\u00fcy\u00fctmek ve yaralar\u0131 s\u0131k\u0131la\u015ft\u0131rmak i\u00e7in b\u00fcz\u00fcc\u00fc ba\u011f\u0131rsaklar<\/td>\n<\/tr>\n \n Sark\u0131t<\/td>\n CaCO3<\/sub><\/td>\n Akci\u011ferleri \u0131s\u0131t\u0131n ve yang’a yard\u0131mc\u0131 olun, ast\u0131m\u0131 rahatlat\u0131n ve g\u00f6\u011f\u00fcsleri rahatlat\u0131n<\/td>\n<\/tr>\n \n ercik<\/td>\n Ca ve Mg’nin Karbonat\u0131<\/td>\n \u0130shal, yak\u0131nsama ve kanamay\u0131 durdurmak i\u00e7in b\u00fcz\u00fcc\u00fc ba\u011f\u0131rsaklar<\/td>\n<\/tr>\n \n Yu Yuliang<\/td>\n Fe2<\/sub>O3<\/sub>\u00b73H2<\/sub>O<\/td>\n \u0130shal, yak\u0131nsama ve kanamay\u0131 durdurmak i\u00e7in b\u00fcz\u00fcc\u00fc ba\u011f\u0131rsaklar<\/td>\n<\/tr>\n \n alt\u0131n ta\u015f<\/td>\n K, Mg, Al ve silisik asit<\/td>\n Balgam\u0131 b\u0131rak\u0131n ve qi’yi d\u00fc\u015f\u00fcr\u00fcn, karaci\u011feri sakinle\u015ftirin ve konv\u00fclsiyonlar\u0131 rahatlat\u0131n<\/td>\n<\/tr>\n \n Mavi Ta\u015f<\/td>\n Mg, Al, Fe ve silisik asit<\/td>\n Balgam\u0131 b\u0131rak\u0131n ve qi’yi d\u00fc\u015f\u00fcr\u00fcn, karaci\u011feri sakinle\u015ftirin ve konv\u00fclsiyonlar\u0131 rahatlat\u0131n<\/td>\n<\/tr>\n \n Montmorillonit<\/td>\n al\u00fcminosilikat<\/td>\n Kanamay\u0131 ve ishali durdurun, \u00fclserleri tedavi edin<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n