![\"\"](\"https:\/\/www.alpapowder.com\/wp-content\/uploads\/2023\/11\/API-production-line.webp\")
<\/p>\n<\/p>\n
Oral kat\u0131 dozaj formlar\u0131n\u0131n \u00fcretim s\u00fcrecinde, toplu ila\u00e7 k\u0131rma genellikle son derece kritik bir \u00fcnite i\u015flemidir. Bir yandan API’nin par\u00e7ac\u0131k boyutu ila\u00e7 emilimini etkileyebilir. Az \u00e7\u00f6z\u00fcnen oral kat\u0131 preparasyonlar i\u00e7in, ham maddenin par\u00e7ac\u0131k boyutu ne kadar k\u00fc\u00e7\u00fck olursa, \u00e7\u00f6z\u00fcnme o kadar h\u0131zl\u0131 olur ve ilac\u0131n biyoyararlan\u0131m\u0131 da geli\u015ftirilebilir. Ayr\u0131ca API’nin par\u00e7ac\u0131k boyutu, tozun ak\u0131\u015fkanl\u0131\u011f\u0131, kar\u0131\u015ft\u0131rma i\u015flemi ve tozun tabakala\u015fmas\u0131 \u00fczerinde \u00f6nemli bir etkiye sahiptir ve bu fakt\u00f6rler, \u00fcretim s\u00fcrecinin stabilitesi \u00fczerinde \u00f6nemli bir etkiye sahiptir.<\/p>\n
Sentez s\u00fcrecinde, oral kat\u0131 dozaj formlar\u0131 i\u00e7in ham maddeler s\u0131kl\u0131kla kristalizasyon yoluyla elde edilir. Kristalizasyon prosesinin kontrol edilmesiyle hammadde ilac\u0131n partik\u00fcl boyutu belli bir dereceye kadar kontrol edilebilmektedir. Ancak \u00e7o\u011fu durumda kristalle\u015ftirme yoluyla elde edilen API’nin par\u00e7ac\u0131k boyutu ve par\u00e7ac\u0131k boyutu da\u011f\u0131l\u0131m\u0131 \u00e7o\u011fu zaman preparat\u0131n ihtiya\u00e7lar\u0131n\u0131 kar\u015f\u0131layamaz. Bu nedenle, preparat \u00fcretimi s\u0131ras\u0131nda API’nin daha fazla i\u015flenmesi, yani par\u00e7ac\u0131k boyutunun hedef aral\u0131k dahilinde kontrol edilmesi i\u00e7in API’nin ezilmesi gereklidir.<\/p>\n
Genel olarak \u00f6\u011f\u00fctme y\u00f6ntemleri, \u00f6\u011f\u00fctme s\u0131ras\u0131nda da\u011f\u0131lan farkl\u0131 ortamlara g\u00f6re kuru ve \u0131slak y\u00f6ntemlere ayr\u0131labilir. Islak y\u00f6ntem API’yi toz haline getirmek i\u00e7in s\u0131v\u0131 bir ortamda da\u011f\u0131tmakt\u0131r; kuru y\u00f6ntem ise API’yi bir gaz (hava, nitrojen vb.) i\u00e7inde toz haline getirmektir. Kuru y\u00f6ntem \u00e7o\u011funlukla kat\u0131 preparasyonlar\u0131n hammaddelerini k\u0131rmak i\u00e7in kullan\u0131l\u0131r.<\/p>\n
\u00c7eki\u00e7li de\u011firmenin k\u0131rma prensibi esas olarak ham ila\u00e7 par\u00e7ac\u0131klar\u0131n\u0131 y\u00fcksek h\u0131zl\u0131 d\u00f6nen \u00e7eki\u00e7ler\/\u00e7eki\u00e7ler arac\u0131l\u0131\u011f\u0131yla s\u00fcrekli olarak d\u00f6vmektir ve par\u00e7ac\u0131klar ayr\u0131ca k\u0131rma bo\u015flu\u011fuyla veya par\u00e7ac\u0131klar aras\u0131nda \u00e7arp\u0131\u015f\u0131r. Bu i\u015flemler par\u00e7ac\u0131k boyutunu etkili bir \u015fekilde azaltabilir. Par\u00e7ac\u0131k boyutu se\u00e7ilen elek deliklerinden ge\u00e7ebilecek kadar k\u00fc\u00e7\u00fck oldu\u011funda k\u0131rma odas\u0131ndan bo\u015falt\u0131lacakt\u0131r. \u00c7eki\u00e7li de\u011firmen b\u00fcy\u00fck bir \u00fcretim kapasitesine ve d\u00fc\u015f\u00fck enerji t\u00fcketimine sahiptir ve k\u0131r\u0131lgan ila\u00e7lar\u0131 k\u0131rmak i\u00e7in daha uygundur. Baz\u0131 viskoz malzemeler, mekanik dayak yoluyla par\u00e7ac\u0131k k\u0131r\u0131lmas\u0131na yatk\u0131n de\u011fildir ve \u00e7eki\u00e7le k\u0131rmaya uygun de\u011fildir. Ancak malzemelerin k\u0131r\u0131lganl\u0131\u011f\u0131n\u0131 artt\u0131rmak ve ezilme kolayl\u0131\u011f\u0131n\u0131 artt\u0131rmak i\u00e7in malzemeler so\u011futulabilir. Ayr\u0131ca \u00e7eki\u00e7le k\u0131rma ciddi \u0131s\u0131 \u00fcretti\u011finden malzemenin stabilitesine dikkat edilmelidir. Erime noktas\u0131 100\u00b0C’nin alt\u0131nda olan bile\u015fikler \u00e7eki\u00e7le k\u0131rma gibi mekanik k\u0131rma y\u00f6ntemlerine uygun de\u011fildir. \u00c7eki\u00e7li de\u011firmenler genellikle 10 \u00b5m’nin \u00fczerindeki partik\u00fcl boyutlar\u0131n\u0131n k\u0131r\u0131lmas\u0131 i\u00e7in uygundur. \u00c7eki\u00e7li de\u011firmenin k\u0131rma etkisiyle ilgili fakt\u00f6rler genellikle \u00e7eki\u00e7 b\u0131\u00e7a\u011f\u0131n\u0131n \u015fekli ve montaj y\u00f6ntemini, d\u00f6n\u00fc\u015f h\u0131z\u0131n\u0131 ve ilerleme h\u0131z\u0131n\u0131 vb. i\u00e7erir.<\/p>\n
Spiral jet pulverizat\u00f6r\u00fc, nispeten basit mekanik yap\u0131ya ve k\u0131rma i\u015flemine sahip, nispeten yayg\u0131n bir hava ak\u0131\u015fl\u0131 pulverizat\u00f6rd\u00fcr. Bas\u0131n\u00e7l\u0131 hava ak\u0131\u015f\u0131, besleme nozulu arac\u0131l\u0131\u011f\u0131yla malzemeleri belirli bir h\u0131zla k\u0131rma odas\u0131na getirir. Halka \u015feklindeki k\u0131rma odas\u0131n\u0131n etraf\u0131ndaki ayn\u0131 d\u00fczlemde, hava ak\u0131\u015f\u0131n\u0131 300 ~ 500 metre\/saniyeye kadar bir h\u0131zla k\u0131rma odas\u0131na p\u00fcsk\u00fcrten, bir girdap hava ak\u0131\u015f\u0131 olu\u015fturan ve k\u0131rma odas\u0131na giren par\u00e7ac\u0131klar\u0131n y\u00fcksek h\u0131zda hareket etmesine neden olan birka\u00e7 noz\u00fcl vard\u0131r. Hava ak\u0131\u015f\u0131 ve par\u00e7ac\u0131klar ve di\u011fer par\u00e7ac\u0131klar veya k\u0131rma odas\u0131 ile h\u0131z. G\u00f6vde \u015fiddetli \u00e7arp\u0131\u015fma ve s\u00fcrt\u00fcnme nedeniyle par\u00e7aland\u0131. K\u0131rma i\u015flemi esas olarak par\u00e7ac\u0131klar aras\u0131ndaki \u00e7arp\u0131\u015fmay\u0131 ve ard\u0131ndan par\u00e7ac\u0131klar ile k\u0131rma bo\u015flu\u011fu aras\u0131ndaki \u00e7arp\u0131\u015fmay\u0131 i\u00e7erir. Par\u00e7ac\u0131klar\u0131n hava ak\u0131\u015f\u0131ndaki dairesel hareketi belirli bir merkezka\u00e7 kuvveti olu\u015fturacakt\u0131r. Ezme ilerledik\u00e7e par\u00e7ac\u0131k boyutu ve k\u00fctlesi azal\u0131r ve al\u0131nan merkezka\u00e7 kuvveti giderek k\u00fc\u00e7\u00fcl\u00fcr. Merkezka\u00e7 kuvveti yeterince k\u00fc\u00e7\u00fck oldu\u011funda, k\u0131rma odas\u0131ndan bo\u015falt\u0131lan hava ak\u0131\u015f\u0131, par\u00e7ac\u0131klar\u0131 girdap hava ak\u0131\u015f\u0131n\u0131n merkezine getirecek ve ard\u0131ndan k\u0131rma i\u015flemini tamamlamak i\u00e7in hava ak\u0131\u015f\u0131yla birlikte k\u0131rma odas\u0131ndan bo\u015falt\u0131lacakt\u0131r. Bu girdapl\u0131 hava ak\u0131\u015f\u0131, k\u0131rma ve s\u0131n\u0131fland\u0131rma i\u015flemlerinin ayn\u0131 anda ger\u00e7ekle\u015ftirilmesine olanak tan\u0131r ve bu da, daha dar par\u00e7ac\u0131k boyutu da\u011f\u0131l\u0131m\u0131na sahip bir nihai \u00fcr\u00fcn\u00fcn elde edilmesi a\u00e7\u0131s\u0131ndan faydal\u0131d\u0131r.<\/p>\n","protected":false},"excerpt":{"rendered":"
Sentez s\u00fcrecinde, oral kat\u0131 dozaj formlar\u0131 i\u00e7in ham maddeler s\u0131kl\u0131kla kristalizasyon yoluyla elde edilir.<\/p>\n","protected":false},"author":7,"featured_media":129996,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[851],"tags":[],"class_list":["post-130029","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-endustri-haberleri-tr"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.alpapowder.com\/tr\/wp-json\/wp\/v2\/posts\/130029"}],"collection":[{"href":"https:\/\/www.alpapowder.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.alpapowder.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.alpapowder.com\/tr\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/www.alpapowder.com\/tr\/wp-json\/wp\/v2\/comments?post=130029"}],"version-history":[{"count":0,"href":"https:\/\/www.alpapowder.com\/tr\/wp-json\/wp\/v2\/posts\/130029\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.alpapowder.com\/tr\/wp-json\/wp\/v2\/media\/129996"}],"wp:attachment":[{"href":"https:\/\/www.alpapowder.com\/tr\/wp-json\/wp\/v2\/media?parent=130029"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.alpapowder.com\/tr\/wp-json\/wp\/v2\/categories?post=130029"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.alpapowder.com\/tr\/wp-json\/wp\/v2\/tags?post=130029"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}