{"id":130297,"date":"2023-12-11T10:52:35","date_gmt":"2023-12-11T02:52:35","guid":{"rendered":"https:\/\/www.alpapowder.com\/130297\/"},"modified":"2023-12-11T10:53:31","modified_gmt":"2023-12-11T02:53:31","slug":"how-much-do-you-know-about-medicinal-talc","status":"publish","type":"post","link":"https:\/\/www.alpapowder.com\/tr\/130297\/","title":{"rendered":"T\u0131bbi talk hakk\u0131nda ne kadar bilginiz var?"},"content":{"rendered":"

\"\"<\/p>\n

\u0130la\u00e7 end\u00fcstrisinde talk tozunun geni\u015f ve uzun bir kullan\u0131m ge\u00e7mi\u015fi vard\u0131r. Genellikle tabletler ve kaps\u00fcller gibi oral kat\u0131 preparatlarda kayganla\u015ft\u0131r\u0131c\u0131 ve seyreltici olarak kullan\u0131l\u0131r.<\/p>\n

Talk tozunun ana bile\u015feni, esas olarak magnezyum oksit, silikon dioksit ve az miktarda sudan olu\u015fan sulu magnezyum silikatt\u0131r.<\/p>\n

(1) Talk tozunun yap\u0131s\u0131<\/p>\n

Talk pudras\u0131 pul pul bir yap\u0131ya sahiptir ve monoklinik kristal sistemine aittir. Kristaller pul pul olup, temel birim lamellerdir. Farkl\u0131 lameller zay\u0131f van der Waals kuvvetleriyle birbirine ba\u011flan\u0131r. D\u0131\u015f kuvvetler taraf\u0131ndan kesildi\u011finde katmanlar aras\u0131nda soyulman\u0131n meydana gelmesi kolayd\u0131r. , kayma fenomeni. Talk tozu par\u00e7ac\u0131klar\u0131 genellikle yaprak \u015feklinde veya radyal, renksiz, tats\u0131z ve kokusuzdur, m\u00fckemmel fiziksel \u00f6zelliklere sahiptir ve suda \u00e7\u00f6z\u00fcnmez.<\/p>\n

(2) Talk tozunun fiziksel ve kimyasal \u00f6zellikleri<\/p>\n

Talk pudras\u0131, beyaz veya kirli beyaz, kumsuz, yar\u0131lma y\u00fczeyinde inci parlakl\u0131\u011f\u0131na sahip ince bir tozdur. Kokusuz ve tats\u0131zd\u0131r, ya\u011fl\u0131 bir his verir ve cilde yap\u0131\u015fmas\u0131 kolayd\u0131r. Suda, seyreltik hidroklorik asitte veya %8,5 sodyum hidroksit \u00e7\u00f6zeltisinde \u00e7\u00f6z\u00fclebilir. \u00c7\u00f6z\u00fcnmez. Sertlik 1,0~1,5, k\u0131r\u0131lma indisi 1,54~1,59 ve \u00f6zg\u00fcl a\u011f\u0131rl\u0131k 2,7~2,8’dir.<\/p>\n

(3) Talk tozunun i\u015flenmesi<\/p>\n

Raymond de\u011firmeni, mekanik darbeli k\u0131r\u0131c\u0131, jet de\u011firmeni ve di\u011fer ekipmanlar talk pudras\u0131n\u0131n \u00f6\u011f\u00fct\u00fclmesinde yayg\u0131n olarak kullan\u0131lmaktad\u0131r. Y\u00fcksek bas\u0131n\u00e7l\u0131 s\u00fcspansiyonlu valsli de\u011firmen ve Raymond de\u011firmeni, daha b\u00fcy\u00fck par\u00e7ac\u0131k boyutuna sahip talk tozunun i\u015flenmesi i\u00e7in uygundur; ultra ince \u00f6\u011f\u00fctme de\u011firmeni ise esas olarak daha k\u00fc\u00e7\u00fck par\u00e7ac\u0131k boyutuna sahip talk tozunun i\u015flenmesi i\u00e7in kullan\u0131l\u0131r.<\/p>\n

T\u0131bbi talk\u0131n toz haline getirilmesinden sonra, asbest (tremolit), karbon, dolomit, demir oksit ve di\u011fer \u00e7e\u015fitli al\u00fcminyum tuzlar\u0131 ve karbonat mineralleri gibi \u00e7e\u015fitli yabanc\u0131 maddeleri \u00e7\u0131karmak i\u00e7in y\u00fczd\u00fcr\u00fclmesi, daha sonra ince toz haline getirilmesi ve seyreltik olarak i\u015flenmesi gerekir. hidroklorik asit, suyla y\u0131kand\u0131 ve sonra kurutuldu.<\/p>\n

 <\/p>\n

Talk pudras\u0131n\u0131n haz\u0131rlama teknolojisinde uygulanmas\u0131<\/p>\n

(1) U\u00e7ucu ya\u011flar i\u00e7in da\u011f\u0131t\u0131c\u0131 olarak kullan\u0131l\u0131r<\/p>\n

Talk tozunun belirli bir adsorpsiyon kapasitesi oldu\u011fundan, u\u00e7ucu ya\u011f\u0131 par\u00e7ac\u0131klar\u0131n\u0131n y\u00fczeyine adsorbe edebilir ve e\u015fit \u015fekilde da\u011f\u0131tabilir. U\u00e7ucu ya\u011f ile s\u0131v\u0131 ila\u00e7 aras\u0131ndaki temas alan\u0131n\u0131 artt\u0131rarak u\u00e7ucu ya\u011f\u0131n \u00e7\u00f6z\u00fcn\u00fcrl\u00fc\u011f\u00fcn\u00fc artt\u0131r\u0131r.<\/p>\n

(2) Toz boya tabakas\u0131yla \u00f6rt\u00fcn<\/p>\n

\u015eeker kaplamada, toz kaplama katman\u0131n\u0131 kaplamak i\u00e7in talk tozu kullan\u0131labilir. 100 g\u00f6zenekli elekten ge\u00e7en beyaz talk tozu uygundur. Dozaj genellikle %3 ila %6 aras\u0131ndad\u0131r. Sadece kenarlar\u0131 ve k\u00f6\u015feleri ortadan kald\u0131rmak ve kaplamay\u0131 kolayla\u015ft\u0131rmakla kalmaz, ayn\u0131 zamanda \u015feker kapl\u0131 tabletlerin stabilitesini de geli\u015ftirebilir.<\/p>\n

(3) Ya\u011flay\u0131c\u0131 olarak kullan\u0131l\u0131r<\/p>\n

\u015eu anda, talk tozu genellikle da\u011f\u0131labilir tabletler, kaps\u00fcller, \u00e7i\u011fnenebilir tabletler, efervesan tabletler ve s\u00fcrekli sal\u0131ml\u0131 tabletlerin re\u00e7etelerinde kayganla\u015ft\u0131r\u0131c\u0131 olarak kullan\u0131lmaktad\u0131r. Talk tozu, ila\u00e7 tozlar\u0131n\u0131n y\u00fczeyindeki \u00e7\u00f6k\u00fcnt\u00fcleri doldurarak ila\u00e7 tozlar\u0131 aras\u0131ndaki s\u00fcrt\u00fcnmeyi azaltabilir ve ila\u00e7 tozlar\u0131n\u0131n ak\u0131\u015fkanl\u0131\u011f\u0131n\u0131 geli\u015ftirebilir.<\/p>\n

(4) Filtre yard\u0131mc\u0131s\u0131 olarak kullan\u0131l\u0131r<\/p>\n

Talk tozunun ila\u00e7larla reaksiyona girmesi kolay de\u011fildir ve belirli bir adsorpsiyon kapasitesine sahiptir, bu nedenle filtre yard\u0131mc\u0131s\u0131 olarak kullan\u0131labilir. 115\u00b0C’de aktive edilen talk tozu, t\u0131bbi \u00e7\u00f6zeltiye s\u0131cakken eklendi\u011finde, ilac\u0131n aktif bile\u015fenlerine zarar vermeden az miktarda polisakkarit, mukus ve sak\u0131z yabanc\u0131 maddelerini emebilir.<\/p>\n

 <\/p>\n

Talk tozunun farmas\u00f6tik yard\u0131mc\u0131 madde olarak uygulanmas\u0131<\/p>\n

(1) Hidrofobik ila\u00e7lar i\u00e7in par\u00e7alay\u0131c\u0131 olarak kullan\u0131l\u0131r<\/p>\n

\u0130lac\u0131n i\u00e7ine talk pudras\u0131 eklendikten sonra, hidrofilik bir madde oldu\u011fu i\u00e7in ilac\u0131n tamam\u0131n\u0131n hidrofilikli\u011fini art\u0131rabilir, suyun ilac\u0131n i\u00e7ine n\u00fcfuz etmesini ve par\u00e7alanmas\u0131n\u0131 kolayla\u015ft\u0131rabilir. Bu nedenle ilac\u0131n par\u00e7alanma s\u00fcresini k\u0131saltmak i\u00e7in talk tozu par\u00e7alay\u0131c\u0131 olarak kullan\u0131labilir. \u00f6zellikle hidrofobik ila\u00e7lar i\u00e7in.<\/p>\n

(2) Yap\u0131\u015fmaz madde olarak kullan\u0131l\u0131r<\/p>\n

Yap\u0131\u015fkanl\u0131k sorunu, kaplama i\u015fleminde yayg\u0131n bir sorundur ve yava\u015f kaplama h\u0131z\u0131na, daha uzun \u00fcretim d\u00f6ng\u00fcs\u00fcne, pelet yap\u0131\u015fmas\u0131na, verimin azalmas\u0131na, film hasar\u0131na, ila\u00e7 sal\u0131n\u0131m\u0131n\u0131n etkilenmesine ve di\u011fer sorunlara yol a\u00e7abilir.<\/p>\n

(3) \u0130lac\u0131n kritik ba\u011f\u0131l nemini artt\u0131r\u0131n<\/p>\n

Nemi kolayca emen ila\u00e7lar i\u00e7in ilac\u0131n stabilitesini art\u0131rmak amac\u0131yla re\u00e7eteye talk pudras\u0131 eklenebilir.<\/p>\n

(4) \u0130la\u00e7 sal\u0131n\u0131m\u0131n\u0131 etkilemek<\/p>\n

Literat\u00fcrde fonksiyonel kaplama form\u00fclasyonlar\u0131nda \u00e7\u00f6z\u00fcnmeyen par\u00e7ac\u0131klar\u0131n ila\u00e7 sal\u0131m \u00f6zelliklerini etkileyebildi\u011fi ancak sonu\u00e7lar\u0131n ve etki mekanizmalar\u0131n\u0131n farkl\u0131 oldu\u011fu rapor edilmi\u015ftir.<\/p>\n","protected":false},"excerpt":{"rendered":"

Talk tozunun ana bile\u015feni, esas olarak magnezyum oksit, silikon dioksit ve az miktarda sudan olu\u015fan sulu magnezyum silikatt\u0131r.<\/p>\n","protected":false},"author":7,"featured_media":130260,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[851],"tags":[],"class_list":["post-130297","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-endustri-haberleri-tr"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.alpapowder.com\/tr\/wp-json\/wp\/v2\/posts\/130297"}],"collection":[{"href":"https:\/\/www.alpapowder.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.alpapowder.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.alpapowder.com\/tr\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/www.alpapowder.com\/tr\/wp-json\/wp\/v2\/comments?post=130297"}],"version-history":[{"count":0,"href":"https:\/\/www.alpapowder.com\/tr\/wp-json\/wp\/v2\/posts\/130297\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.alpapowder.com\/tr\/wp-json\/wp\/v2\/media\/130260"}],"wp:attachment":[{"href":"https:\/\/www.alpapowder.com\/tr\/wp-json\/wp\/v2\/media?parent=130297"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.alpapowder.com\/tr\/wp-json\/wp\/v2\/categories?post=130297"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.alpapowder.com\/tr\/wp-json\/wp\/v2\/tags?post=130297"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}