{"id":134923,"date":"2024-11-08T11:16:03","date_gmt":"2024-11-08T03:16:03","guid":{"rendered":"https:\/\/www.alpapowder.com\/134923\/"},"modified":"2024-11-08T11:16:05","modified_gmt":"2024-11-08T03:16:05","slug":"saglikta-bor-nitrur-uygulamalari","status":"publish","type":"post","link":"https:\/\/www.alpapowder.com\/tr\/134923\/","title":{"rendered":"Sa\u011fl\u0131kta Bor Nitr\u00fcr Uygulamalar\u0131"},"content":{"rendered":"

\"\"<\/p>\n

Bor nitr\u00fcr, \u00fc\u00e7\u00fcnc\u00fc ana grup elementi bor ve be\u015finci ana grup elementi azottan olu\u015fan alt\u0131gen d\u00fczenli a\u011f yap\u0131s\u0131na sahip katmanl\u0131 bir molek\u00fcler kristaldir. Molek\u00fcler kristal tabakas\u0131nda, bor atomlar\u0131 ve azot atomlar\u0131 koordinasyon ba\u011flar\u0131yla birle\u015ftirilir ve koordinasyon ba\u011f\u0131 ba\u011flama kuvveti \u00e7ok g\u00fc\u00e7l\u00fcd\u00fcr, bu nedenle tabakadaki B atomlar\u0131 ve N atomlar\u0131 s\u0131k\u0131ca ba\u011fl\u0131d\u0131r. Katmanlar molek\u00fcler ba\u011flarla birbirine ba\u011flan\u0131r. Molek\u00fcler ba\u011flar zay\u0131f oldu\u011fundan, katmanlar aras\u0131nda d\u00fc\u015fmek \u00e7ok kolayd\u0131r.<\/p>\n

Farkl\u0131 kristal formlar\u0131na g\u00f6re, bor nitr\u00fcr\u00fcn kristal yap\u0131s\u0131 esas olarak d\u00f6rt t\u00fcre ayr\u0131labilir: hekzagonal bor nitr\u00fcr (h-BN), k\u00fcbik bor nitr\u00fcr (c-BN), wurtzit bor nitr\u00fcr (w-BN) ve rombohedral bor nitr\u00fcr (r-BN). Bunlar aras\u0131nda hekzagonal bor nitr\u00fcr (h-BN) en yayg\u0131n kullan\u0131lan\u0131d\u0131r.<\/p>\n

Bor Nitr\u00fcr’\u00fcn Biyomedikal Alanda Uygulanmas\u0131<\/p>\n

BN, in vitro ve in vivo iyi biyouyumlulu\u011fa sahiptir ve biyolojik uygulamalarda grafen bazl\u0131 malzemelerin benzer veya hatta daha \u00fcst\u00fcn \u00f6zelliklerine sahiptir. Antibakteriyel, ila\u00e7 da\u011f\u0131t\u0131m\u0131, bor da\u011f\u0131t\u0131m maddesi, doku m\u00fchendisli\u011fi, in vivo g\u00f6r\u00fcnt\u00fcleme ve di\u011fer alanlarda kullan\u0131labilir.<\/p>\n

(1) Antibakteriyel<\/p>\n

Son zamanlarda, baz\u0131 \u00e7al\u0131\u015fmalar bor nitr\u00fcr nanosayfalar\u0131n\u0131n antimikrobiyal diren\u00e7li (AMR) bakteriler \u00fczerinde etkili antibakteriyel etkilere sahip oldu\u011funu ve uzun s\u00fcreli kullan\u0131mda ikincil ila\u00e7 direncine neden olmadan v\u00fccutta iyi biyouyumlulu\u011fa sahip oldu\u011funu bulmu\u015ftur.<\/p>\n

(2) \u0130la\u00e7 da\u011f\u0131t\u0131m\u0131<\/p>\n

h-BN ayr\u0131ca umut vadeden bir ila\u00e7 ta\u015f\u0131y\u0131c\u0131s\u0131 olarak kabul edilir. Alt\u0131gen bor nitr\u00fcr nanosayfalar\u0131 (BNNS’ler) tuz \u015fablonu y\u00f6ntemi ile bir seferde b\u00fcy\u00fck miktarlarda sentezlendi ve in vivo ve in vitro deneylerde meme kanserinin \u00e7o\u011falmas\u0131n\u0131 etkili bir \u015fekilde engelledi, bu da BNNS’lerin ila\u00e7 da\u011f\u0131t\u0131m uygulamalar\u0131ndaki potansiyelini g\u00f6stermektedir. Baz\u0131 \u00e7al\u0131\u015fmalar, ta\u015f\u0131y\u0131c\u0131 olarak k\u00fcresel BN kullan\u0131ld\u0131\u011f\u0131nda, deoksiribon\u00fckleik asit y\u00fckl\u00fc beyin natri\u00fcretik peptidinin endositoz yoluyla t\u00fcm\u00f6rl\u00fc IAR-6-1 h\u00fccrelerine n\u00fcfuz etti\u011fini ve daha sonra sitoplazmaya ve \u00e7ekirde\u011fe DOX sald\u0131\u011f\u0131n\u0131, b\u00f6ylece kanser h\u00fccrelerini hedef ald\u0131\u011f\u0131n\u0131 ve \u00f6ld\u00fcrd\u00fc\u011f\u00fcn\u00fc bulmu\u015ftur.<\/p>\n

(3) Doku m\u00fchendisli\u011fi<\/p>\n

Di\u015f malzemeleri alan\u0131nda, BNN’ler y\u00fcksek enerjili bilyal\u0131 \u00f6\u011f\u00fctme ile haz\u0131rlanm\u0131\u015f ve bir zirkonyum matrisinde da\u011f\u0131t\u0131lm\u0131\u015f ve kompozit toz plazma sinterleme ile konsolide edilmi\u015ftir. BNN’ler eklenmi\u015f zirkonyum, %27,3’e kadar bir mukavemet ve %37,5’lik bir k\u0131r\u0131lma toklu\u011fu g\u00f6stermi\u015f ve nemli bir ortamda zirkonyum matrisinin bozulmas\u0131n\u0131 engellemi\u015ftir, bu da BNN’lerin bir di\u015f malzemesi takviyesi olarak potansiyel de\u011ferini g\u00f6stermektedir.<\/p>\n

(4) Bor iletim ajan\u0131<\/p>\n

Y\u00fcksek bor i\u00e7eri\u011fi ve d\u00fc\u015f\u00fck sitotoksisitesi nedeniyle, Bor nitr\u00fcr nanomalzemeleri bor n\u00f6tron yakalama terapisi (BNCT) i\u00e7in bor iletim ajan\u0131 olarak kullan\u0131labilir. BNCT, normal h\u00fccrelere zarar vermeden kanser h\u00fccrelerini hedef alabilen ve \u00f6ld\u00fcrebilen yeni bir t\u00fcr spesifik radyasyon kanser tedavisidir. Polietilen glikol ile modifiye edilmi\u015f bor nitr\u00fcr nanot\u00fcplerinin BNCT i\u00e7in bor iletim ajan\u0131 oldu\u011fu g\u00f6sterilmi\u015ftir. B16 melanom h\u00fccrelerindeki bor birikimi, ikinci nesil bor iletim ajan\u0131 BSH’nin (disodyum tiyododekaboran) yakla\u015f\u0131k \u00fc\u00e7 kat\u0131d\u0131r. Polilizin ve folik asit ile modifiye edilmi\u015f bor nitr\u00fcr nanot\u00fcpleri, floresan kuantum noktalar\u0131yla birle\u015ftirildikten sonra glioblastoma multiforme h\u00fccreleri taraf\u0131ndan se\u00e7ici olarak al\u0131n\u0131r. Bunlar yaln\u0131zca BNCT i\u00e7in bor iletim ajan\u0131 olarak kullan\u0131lamaz, ayn\u0131 zamanda ila\u00e7lar\u0131n h\u00fccre i\u00e7i davran\u0131\u015f\u0131n\u0131 da izleyebilir. Bor nitr\u00fcr nanok\u00fcrelerinin ayr\u0131ca prostat kanserinin tedavisi i\u00e7in y\u00fcksek kaliteli bir bor rezervuar\u0131 oldu\u011fu bildirilmi\u015ftir. Kontrol edilebilir kristaliniteye sahip bor nitr\u00fcr, s\u00fcrekli olarak bor salabilir, b\u00f6ylece prostat kanseri h\u00fccrelerinin aktivitesini azaltabilir ve h\u00fccre apoptozunu ind\u00fckleyebilir. \u0130n situ t\u00fcm\u00f6r modeli, i\u00e7i bo\u015f bor nitr\u00fcr k\u00fcrelerinin in vivo kanser kar\u015f\u0131t\u0131 etkinli\u011fini do\u011frulad\u0131.<\/p>\n","protected":false},"excerpt":{"rendered":"

Bor nitr\u00fcr, \u00fc\u00e7\u00fcnc\u00fc ana grup elementi bor ve be\u015finci ana grup elementi azottan olu\u015fan alt\u0131gen d\u00fczenli a\u011f yap\u0131l\u0131, katmanl\u0131 bir molek\u00fcler kristaldir.<\/p>\n","protected":false},"author":7,"featured_media":134890,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[851],"tags":[],"class_list":["post-134923","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-endustri-haberleri-tr"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.alpapowder.com\/tr\/wp-json\/wp\/v2\/posts\/134923","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.alpapowder.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.alpapowder.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.alpapowder.com\/tr\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/www.alpapowder.com\/tr\/wp-json\/wp\/v2\/comments?post=134923"}],"version-history":[{"count":1,"href":"https:\/\/www.alpapowder.com\/tr\/wp-json\/wp\/v2\/posts\/134923\/revisions"}],"predecessor-version":[{"id":134924,"href":"https:\/\/www.alpapowder.com\/tr\/wp-json\/wp\/v2\/posts\/134923\/revisions\/134924"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.alpapowder.com\/tr\/wp-json\/wp\/v2\/media\/134890"}],"wp:attachment":[{"href":"https:\/\/www.alpapowder.com\/tr\/wp-json\/wp\/v2\/media?parent=134923"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.alpapowder.com\/tr\/wp-json\/wp\/v2\/categories?post=134923"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.alpapowder.com\/tr\/wp-json\/wp\/v2\/tags?post=134923"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}