{"id":119522,"date":"2022-10-31T13:15:45","date_gmt":"2022-10-31T05:15:45","guid":{"rendered":"https:\/\/www.alpapowder.com\/119522\/"},"modified":"2022-11-01T13:21:01","modified_gmt":"2022-11-01T05:21:01","slug":"cam-mau-khang-khuan-van-chuyen-thuoc-kaolin-co-tiem-nang-vo-han-trong-linh-vuc-y-sinh-hoc","status":"publish","type":"post","link":"https:\/\/www.alpapowder.com\/vi\/119522\/","title":{"rendered":"C\u1ea7m m\u00e1u, kh\u00e1ng khu\u1ea9n, v\u1eadn chuy\u1ec3n thu\u1ed1c, kaolin c\u00f3 ti\u1ec1m n\u0103ng v\u00f4 h\u1ea1n trong l\u0129nh v\u1ef1c y sinh h\u1ecdc!"},"content":{"rendered":"

\"\"<\/p>\n

V\u1eadt li\u1ec7u kho\u00e1ng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng r\u1ed9ng r\u00e3i trong y sinh v\u00e0 c\u00f3 l\u1ecbch s\u1eed l\u00e2u \u0111\u1eddi.<\/p>\n

1. V\u1eadt li\u1ec7u c\u1ea7m m\u00e1u<\/p>\n

“Compendium of Materia Medica” ghi: Baishizhi v\u1edbi th\u00e0nh ph\u1ea7n ch\u00ednh l\u00e0 cao lanh c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 h\u1ea5p th\u1ee5 c\u00e1c ch\u1ea5t \u0111\u1ed9c h\u1ea1i, l\u00e0m se v\u00e0 r\u1eafn l\u1ea1i, c\u1ea7m m\u00e1u v\u00e0 \u1ee9c ch\u1ebf b\u00e0i ti\u1ebft. N\u0103m 2006, c\u00f4ng ty Z-Medica c\u1ee7a M\u1ef9 \u0111\u00e3 ph\u00e1t tri\u1ec3n m\u1ed9t s\u1ea3n ph\u1ea9m c\u1ea7m m\u00e1u cao lanh g\u1ecdi l\u00e0 “b\u0103ng g\u1ea1c v\u1ebft th\u01b0\u01a1ng chi\u1ebfn tranh”, \u0111\u01b0\u1ee3c \u00e1p d\u1ee5ng cho c\u00e1c b\u1ed9 ph\u1eadn \u0111\u1eb7c bi\u1ec7t, n\u01a1i kh\u00f4ng th\u1ec3 s\u1eed d\u1ee5ng gar\u00f4. N\u00f3 c\u00f3 t\u00ednh di \u0111\u1ed9ng, d\u1ec5 s\u1eed d\u1ee5ng v\u00e0 hi\u1ec7u qu\u1ea3, v\u00e0 c\u00f3 th\u1eddi h\u1ea1n s\u1eed d\u1ee5ng l\u00e0 5 n\u0103m.<\/p>\n

M\u1ed9t lo\u1ea1i h\u1ed7n h\u1ee3p nano oxit s\u1eaft \/ cao lanh m\u1edbi \u0111\u00e3 \u0111\u01b0\u1ee3c t\u1ed5ng h\u1ee3p th\u00e0nh c\u00f4ng d\u1ef1a tr\u00ean ch\u1ea5t c\u1ea7m m\u00e1u t\u1ef1 nhi\u00ean thay cho \u0111\u1ea5t son \u0111\u1ec3 ki\u1ec3m so\u00e1t xu\u1ea5t huy\u1ebft. H\u00ecnh th\u00e1i c\u1ee7a oxit c\u00f3 \u1ea3nh h\u01b0\u1edfng \u0111\u00e1ng k\u1ec3 \u0111\u1ebfn t\u00e1c d\u1ee5ng c\u1ea7m m\u00e1u c\u1ee7a n\u00f3.<\/p>\n

C\u00e1c \u0111\u1eb7c t\u00ednh c\u1ea7m m\u00e1u trong \u1ed1ng nghi\u1ec7m c\u1ee7a Quikclot, m\u1ed9t ch\u1ea5t c\u1ea7m m\u00e1u d\u1ef1a tr\u00ean zeolit \u200b\u200bth\u01b0\u01a1ng m\u1ea1i truy\u1ec1n th\u1ed1ng v\u00e0 c\u00e1c silicat ph\u00e2n l\u1edbp \u0111\u00e3 \u0111\u01b0\u1ee3c so s\u00e1nh, v\u00e0 k\u1ebft qu\u1ea3 cho th\u1ea5y r\u1eb1ng c\u00e1c kho\u00e1ng ch\u1ea5t \u0111\u1ea5t s\u00e9t nhi\u1ec1u l\u1edbp silicat (hydrotalcite t\u1ed5ng h\u1ee3p, chu\u1ed7i montmorillonite, kaolinit) kh\u00f4ng gi\u1ea3i ph\u00f3ng trong qu\u00e1 tr\u00ecnh c\u1ea7m m\u00e1u trong \u1ed1ng nghi\u1ec7m. T\u00ednh ch\u1ea5t \u0111\u00f4ng t\u1ee5 nhi\u1ec7t v\u00e0 r\u1ed9ng r\u00e3i, gi\u00e1 c\u1ea3 th\u1ea5p, t\u00ednh ch\u1ea5t \u1ed5n \u0111\u1ecbnh v\u00e0 kh\u00f4ng \u0111\u1ed9c h\u1ea1i, c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng nh\u01b0 m\u1ed9t ch\u1ea5t \u0111\u00f4ng t\u1ee5 m\u1edbi \u0111\u1ec3 thay th\u1ebf QC.<\/p>\n

Gel b\u1ecdt bi\u1ec3n t\u1ed5ng h\u1ee3p graphene-kaolin<\/a> (GKCS) \u0111\u01b0\u1ee3c t\u1ed5ng h\u1ee3p b\u1eb1ng ph\u01b0\u01a1ng ph\u00e1p th\u1ee7y nhi\u1ec7t. K\u1ebft qu\u1ea3 th\u00ed nghi\u1ec7m t\u1ed5n th\u01b0\u01a1ng \u0111\u1ed9ng m\u1ea1ch th\u1ecf cho th\u1ea5y th\u1eddi gian c\u1ea7m m\u00e1u c\u1ee7a ph\u1ee9c h\u1ee3p l\u00e0 73 \u00b1 12s, hi\u1ec7u su\u1ea5t c\u1ea7m m\u00e1u \u0111\u01b0\u1ee3c c\u1ea3i thi\u1ec7n \u0111\u00e1ng k\u1ec3. Trong th\u1ef1c t\u1ebf, g\u1ea1c t\u1ea9m kaolinit \u0111\u01b0\u1ee3c d\u00f9ng \u0111\u1ec3 c\u1ea7m m\u00e1u sau khi c\u1eaft amidan, v\u00e0 84,8% b\u1ec7nh nh\u00e2n c\u1ea7m m\u00e1u ho\u00e0n to\u00e0n sau 5 ph\u00fat, trong khi ch\u1ec9 34,8% b\u1ec7nh nh\u00e2n d\u00f9ng g\u1ea1c ti\u00eau chu\u1ea9n truy\u1ec1n th\u1ed1ng sau m\u1ed5 c\u1ea7m m\u00e1u.<\/p>\n

2. Ng\u01b0\u1eddi v\u1eadn chuy\u1ec3n thu\u1ed1c<\/p>\n

Kaolin<\/a> c\u00f3 th\u00e0nh ph\u1ea7n \u0111\u01a1n gi\u1ea3n v\u00e0 l\u00e0 m\u1ed9t kho\u00e1ng v\u1eadt silicat ph\u00e2n l\u1edbp 1: 1 \u0111i\u1ec3n h\u00ecnh v\u1edbi t\u1ef7 l\u1ec7 \u0111\u01b0\u1eddng k\u00ednh tr\u00ean b\u1ec1 d\u00e0y l\u1edbn, k\u00edch th\u01b0\u1edbc nh\u1ecf v\u00e0 kh\u1ea3 n\u0103ng t\u01b0\u01a1ng th\u00edch sinh h\u1ecdc t\u1ed1t. V\u00ec v\u1eady, cao lanh c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng nh\u01b0 m\u1ed9t ch\u1ea5t mang \u0111\u1ec3 \u0111\u1ea1t \u0111\u01b0\u1ee3c qu\u00e1 tr\u00ecnh t\u1ea3i v\u00e0 gi\u1ea3i ph\u00f3ng thu\u1ed1c. Tuy nhi\u00ean, do kh\u1ea3 n\u0103ng trao \u0111\u1ed5i ion y\u1ebfu n\u00ean c\u00e1c ph\u00e2n t\u1eed thu\u1ed1c ch\u1ec9 c\u00f3 th\u1ec3 h\u1ea5p ph\u1ee5 tr\u00ean b\u1ec1 m\u1eb7t cao lanh, kh\u00f3 \u0111i v\u00e0o l\u1edbp xen ph\u1ee7, s\u1ef1 k\u1ebft h\u1ee3p kh\u00f4ng \u0111\u1ee7 ch\u1eb7t ch\u1ebd, \u1ea3nh h\u01b0\u1edfng l\u1edbn \u0111\u1ebfn t\u00e1c d\u1ee5ng n\u1ea1p thu\u1ed1c.<\/p>\n

S\u1eed d\u1ee5ng cao lanh sau khi xen metanol l\u00e0m ch\u1ea5t mang, so v\u1edbi cao lanh ch\u01b0a bi\u1ebfn t\u00ednh, sau khi n\u1ea1p thu\u1ed1c h\u00f3a tr\u1ecb ph\u00e2n t\u1eed nh\u1ecf 5-fluorouracil, ng\u01b0\u1eddi ta th\u1ea5y r\u1eb1ng t\u1ea3i cao lanh bi\u1ebfn t\u00ednh cao t\u1edbi 55,4%, cao h\u01a1n 147,3% so v\u1edbi c\u1ee7a cao lanh ch\u01b0a bi\u1ebfn t\u00ednh. . \u0110i\u1ec1u n\u00e0y l\u00e0 do s\u1ef1 gh\u00e9p c\u00e1c nh\u00f3m metoxy gi\u1eefa c\u00e1c l\u1edbp cao lanh s\u1ebd m\u1edf r\u1ed9ng kho\u1ea3ng c\u00e1ch gi\u1eefa c\u00e1c l\u1edbp cao lanh, cung c\u1ea5p c\u00e1c v\u1ecb tr\u00ed ho\u1ea1t \u0111\u1ed9ng m\u1edbi cho c\u00e1c ph\u00e2n t\u1eed thu\u1ed1c v\u00e0 th\u00fac \u0111\u1ea9y s\u1ef1 x\u00e2m nh\u1eadp c\u1ee7a thu\u1ed1c v\u00e0o l\u1edbp xen k\u1ebd.<\/p>\n

3. V\u1eadt li\u1ec7u kh\u00e1ng khu\u1ea9n<\/p>\n

Epoxifloxacin \u0111\u01b0\u1ee3c h\u1ea5p ph\u1ee5 tr\u00ean b\u1ec1 m\u1eb7t c\u1ee7a kaolinit, v\u00e0 l\u01b0\u1ee3ng h\u1ea5p ph\u1ee5 t\u1ed1i \u0111a \u0111\u1ea1t \u0111\u01b0\u1ee3c sau 1 gi\u1edd. So v\u1edbi montmorillonite, kaolinit c\u00f3 kh\u1ea3 n\u0103ng trao \u0111\u1ed5i ion y\u1ebfu h\u01a1n n\u00ean ch\u1ea5t kh\u00e1ng khu\u1ea9n d\u1ec5 gi\u1ea3i ph\u00f3ng h\u01a1n v\u00e0 c\u00f3 t\u00e1c d\u1ee5ng di\u1ec7t khu\u1ea9n t\u1ed1t h\u01a1n. B\u1eb1ng c\u00e1ch \u0111o kh\u1ea3 n\u0103ng h\u1ea5p ph\u1ee5 c\u1ee7a CPB, ng\u01b0\u1eddi ta th\u1ea5y r\u1eb1ng CPB-kaolinit c\u00f3 ho\u1ea1t t\u00ednh kh\u00e1ng khu\u1ea9n khi [CPB] v\u01b0\u1ee3t qu\u00e1 gi\u00e1 tr\u1ecb CMC c\u1ee7a n\u00f3. Khi t\u1ea3i CPB l\u00ean kaolinit cao, t\u1ed5ng \u0111i\u1ec7n t\u00edch chuy\u1ec3n t\u1eeb d\u01b0\u01a1ng sang \u00e2m n\u00ean c\u00f3 kh\u1ea3 n\u0103ng h\u1ea5p ph\u1ee5 v\u00e0 di\u1ec7t khu\u1ea9n. Do \u0111\u00f3, cao lanh c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng t\u1ed1t \u0111\u1ec3 kh\u1eed tr\u00f9ng, v\u00e0 trong qu\u00e1 tr\u00ecnh ph\u00e1t tri\u1ec3n l\u1edbp organoclay nh\u01b0 m\u1ed9t ch\u1ea5t kh\u00e1ng khu\u1ea9n, l\u01b0\u1ee3ng ch\u1ea5t ho\u1ea1t \u0111\u1ed9ng b\u1ec1 m\u1eb7t c\u1ed1 \u0111\u1ecbnh tr\u00ean \u0111\u1ea5t s\u00e9t ph\u1ea3i v\u01b0\u1ee3t qu\u00e1 gi\u00e1 tr\u1ecb CMC.<\/p>\n

4. K\u1ef9 thu\u1eadt m\u00f4<\/p>\n

Gi\u00e0n gi\u00e1o th\u1ee7y tinh sinh h\u1ecdc m\u00ea ho\u1eb7c ba chi\u1ec1u (3D MBG) v\u1edbi c\u1ea5u tr\u00fac trung t\u00ednh v\u00e0 m\u1ea1ng l\u01b0\u1edbi macroporous c\u00f3 t\u00ednh li\u00ean k\u1ebft cao \u0111\u01b0\u1ee3c coi l\u00e0 v\u1eadt li\u1ec7u sinh h\u1ecdc l\u00fd t\u01b0\u1edfng cho c\u00e1c \u1ee9ng d\u1ee5ng m\u00f4 x\u01b0\u01a1ng. Tuy nhi\u00ean, \u0111\u1ed9 gi\u00f2n v\u1ed1n c\u00f3 c\u1ee7a n\u00f3 v\u00e0 \u0111\u1ed9 b\u1ec1n c\u01a1 h\u1ecdc k\u00e9m \u1ea3nh h\u01b0\u1edfng nghi\u00eam tr\u1ecdng \u0111\u1ebfn hi\u1ec7u su\u1ea5t v\u00e0 \u1ee9ng d\u1ee5ng l\u00e2m s\u00e0ng c\u1ee7a n\u00f3.<\/p>\n

Gi\u00e0n gi\u00e1o MBG ba chi\u1ec1u v\u1edbi \u0111\u1ed9 b\u1ec1n c\u01a1 h\u1ecdc tuy\u1ec7t v\u1eddi, kh\u1ea3 n\u0103ng kho\u00e1ng h\u00f3a v\u00e0 ph\u1ea3n \u1ee9ng t\u1ebf b\u00e0o t\u1ed1t \u0111\u00e3 \u0111\u01b0\u1ee3c \u0111i\u1ec1u ch\u1ebf th\u00e0nh c\u00f4ng b\u1eb1ng c\u00e1ch s\u1eed d\u1ee5ng cao lanh l\u00e0m ch\u1ea5t k\u1ebft d\u00ednh v\u00e0 ph\u01b0\u01a1ng ph\u00e1p t\u1ea1o khu\u00f4n m\u1eabu b\u1eb1ng b\u1ecdt polyurethane (PU) s\u1eeda \u0111\u1ed5i. MBG-xk lai ph\u00e1t tri\u1ec3n c\u00f3 \u0111\u1ed9 x\u1ed1p 85%. V\u1edbi s\u1ef1 gia t\u0103ng c\u1ee7a h\u00e0m l\u01b0\u1ee3ng cao lanh (5% -20%), c\u01b0\u1eddng \u0111\u1ed9 n\u00e9n \u0111\u1ea1t t\u1eeb 2,6-6,0MPa, g\u1ea5p kho\u1ea3ng 100 l\u1ea7n so v\u1edbi gi\u00e0n gi\u00e1o MBG m\u1eabu PU truy\u1ec1n th\u1ed1ng. Sau khi th\u00eam cao lanh, m\u00f4i tr\u01b0\u1eddng pH c\u1ee7a gi\u00e0n MBG-10K \u1ed5n \u0111\u1ecbnh v\u00e0 l\u00fd t\u01b0\u1edfng h\u01a1n, kh\u1ea3 n\u0103ng h\u1ea5p ph\u1ee5 protein \u0111\u01b0\u1ee3c n\u00e2ng cao.<\/p>\n

Trong t\u01b0\u01a1ng lai, c\u00e1c nghi\u00ean c\u1ee9u v\u1ec1 c\u1ea5u tr\u00fac v\u00e0 c\u01a1 ch\u1ebf ho\u1ea1t \u0111\u1ed9ng c\u1ee7a cao lanh s\u1ebd chuy\u00ean s\u00e2u v\u00e0 vi m\u00f4 h\u01a1n, v\u00e0 cao lanh s\u1ebd \u0111\u00f3ng m\u1ed9t vai tr\u00f2 l\u1edbn h\u01a1n trong nhi\u1ec1u l\u0129nh v\u1ef1c m\u1edbi n\u1ed5i.<\/p>\n","protected":false},"excerpt":{"rendered":"

V\u1eadt li\u1ec7u kho\u00e1ng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng r\u1ed9ng r\u00e3i trong y sinh v\u00e0 c\u00f3 l\u1ecbch s\u1eed l\u00e2u \u0111\u1eddi.<\/p>\n","protected":false},"author":7,"featured_media":119498,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[830],"tags":[],"class_list":["post-119522","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-industry-news"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.alpapowder.com\/vi\/wp-json\/wp\/v2\/posts\/119522","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.alpapowder.com\/vi\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.alpapowder.com\/vi\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.alpapowder.com\/vi\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/www.alpapowder.com\/vi\/wp-json\/wp\/v2\/comments?post=119522"}],"version-history":[{"count":0,"href":"https:\/\/www.alpapowder.com\/vi\/wp-json\/wp\/v2\/posts\/119522\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.alpapowder.com\/vi\/wp-json\/wp\/v2\/media\/119498"}],"wp:attachment":[{"href":"https:\/\/www.alpapowder.com\/vi\/wp-json\/wp\/v2\/media?parent=119522"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.alpapowder.com\/vi\/wp-json\/wp\/v2\/categories?post=119522"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.alpapowder.com\/vi\/wp-json\/wp\/v2\/tags?post=119522"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}