{"id":134925,"date":"2024-11-08T11:18:48","date_gmt":"2024-11-08T03:18:48","guid":{"rendered":"https:\/\/www.alpapowder.com\/134925\/"},"modified":"2024-11-08T11:18:49","modified_gmt":"2024-11-08T03:18:49","slug":"ung-dung-cua-bo-nitride-trong-y-te","status":"publish","type":"post","link":"https:\/\/www.alpapowder.com\/vi\/134925\/","title":{"rendered":"\u1ee8ng d\u1ee5ng c\u1ee7a Bo Nitride trong Y t\u1ebf"},"content":{"rendered":"

\"\"<\/p>\n

Bo nitrua l\u00e0 tinh th\u1ec3 ph\u00e2n t\u1eed nhi\u1ec1u l\u1edbp c\u00f3 c\u1ea5u tr\u00fac m\u1ea1ng l\u01b0\u1edbi l\u1ee5c gi\u00e1c \u0111\u1ec1u bao g\u1ed3m nguy\u00ean t\u1ed1 nh\u00f3m ch\u00ednh th\u1ee9 ba l\u00e0 bo v\u00e0 nguy\u00ean t\u1ed1 nh\u00f3m ch\u00ednh th\u1ee9 n\u0103m l\u00e0 nit\u01a1. Trong l\u1edbp tinh th\u1ec3 ph\u00e2n t\u1eed, c\u00e1c nguy\u00ean t\u1eed bo v\u00e0 nguy\u00ean t\u1eed nit\u01a1 \u0111\u01b0\u1ee3c k\u1ebft h\u1ee3p b\u1eb1ng li\u00ean k\u1ebft ph\u1ed1i h\u1ee3p v\u00e0 l\u1ef1c li\u00ean k\u1ebft li\u00ean k\u1ebft ph\u1ed1i h\u1ee3p r\u1ea5t m\u1ea1nh, do \u0111\u00f3 c\u00e1c nguy\u00ean t\u1eed B v\u00e0 nguy\u00ean t\u1eed N trong l\u1edbp li\u00ean k\u1ebft ch\u1eb7t ch\u1ebd. C\u00e1c l\u1edbp \u0111\u01b0\u1ee3c k\u1ebft n\u1ed1i b\u1eb1ng li\u00ean k\u1ebft ph\u00e2n t\u1eed. V\u00ec li\u00ean k\u1ebft ph\u00e2n t\u1eed y\u1ebfu n\u00ean r\u1ea5t d\u1ec5 r\u01a1i ra gi\u1eefa c\u00e1c l\u1edbp.<\/p>\n

Theo c\u00e1c d\u1ea1ng tinh th\u1ec3 kh\u00e1c nhau, c\u1ea5u tr\u00fac tinh th\u1ec3 c\u1ee7a bo nitrua ch\u1ee7 y\u1ebfu c\u00f3 th\u1ec3 chia th\u00e0nh b\u1ed1n lo\u1ea1i: bo nitrua l\u1ee5c gi\u00e1c (h-BN), bo nitrua l\u1eadp ph\u01b0\u01a1ng (c-BN), bo nitrua wurtzit (w-BN) v\u00e0 bo nitrua h\u00ecnh thoi (r-BN). Trong s\u1ed1 \u0111\u00f3, bo nitrua l\u1ee5c gi\u00e1c (h-BN) l\u00e0 lo\u1ea1i \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng r\u1ed9ng r\u00e3i nh\u1ea5t.<\/p>\n

\u1ee8ng d\u1ee5ng c\u1ee7a Boron Nitride trong l\u0129nh v\u1ef1c Y sinh<\/p>\n

BN c\u00f3 kh\u1ea3 n\u0103ng t\u01b0\u01a1ng th\u00edch sinh h\u1ecdc t\u1ed1t trong \u1ed1ng nghi\u1ec7m v\u00e0 trong c\u01a1 th\u1ec3 s\u1ed1ng, v\u00e0 c\u00f3 c\u00e1c \u0111\u1eb7c t\u00ednh t\u01b0\u01a1ng t\u1ef1 ho\u1eb7c th\u1eadm ch\u00ed v\u01b0\u1ee3t tr\u1ed9i h\u01a1n c\u00e1c v\u1eadt li\u1ec7u g\u1ed1c graphene trong c\u00e1c \u1ee9ng d\u1ee5ng sinh h\u1ecdc. N\u00f3 c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong kh\u00e1ng khu\u1ea9n, v\u1eadn chuy\u1ec3n thu\u1ed1c, t\u00e1c nh\u00e2n v\u1eadn chuy\u1ec3n boron, k\u1ef9 thu\u1eadt m\u00f4, h\u00ecnh \u1ea3nh trong c\u01a1 th\u1ec3 s\u1ed1ng v\u00e0 c\u00e1c l\u0129nh v\u1ef1c kh\u00e1c.<\/p>\n

(1) Kh\u00e1ng khu\u1ea9n<\/p>\n

G\u1ea7n \u0111\u00e2y, m\u1ed9t s\u1ed1 nghi\u00ean c\u1ee9u \u0111\u00e3 ph\u00e1t hi\u1ec7n ra r\u1eb1ng c\u00e1c t\u1ea5m nano boron nitride c\u00f3 t\u00e1c d\u1ee5ng kh\u00e1ng khu\u1ea9n hi\u1ec7u qu\u1ea3 \u0111\u1ed1i v\u1edbi vi khu\u1ea9n kh\u00e1ng thu\u1ed1c (AMR) v\u00e0 c\u00f3 kh\u1ea3 n\u0103ng t\u01b0\u01a1ng th\u00edch sinh h\u1ecdc t\u1ed1t trong c\u01a1 th\u1ec3 m\u00e0 kh\u00f4ng g\u00e2y ra t\u00ecnh tr\u1ea1ng kh\u00e1ng thu\u1ed1c th\u1ee9 c\u1ea5p trong qu\u00e1 tr\u00ecnh s\u1eed d\u1ee5ng l\u00e2u d\u00e0i.<\/p>\n

(2) V\u1eadn chuy\u1ec3n thu\u1ed1c<\/p>\n

h-BN c\u0169ng \u0111\u01b0\u1ee3c coi l\u00e0 m\u1ed9t ch\u1ea5t mang thu\u1ed1c \u0111\u1ea7y h\u1ee9a h\u1eb9n. C\u00e1c t\u1ea5m nano boron nitride l\u1ee5c gi\u00e1c (BNNS) \u0111\u00e3 \u0111\u01b0\u1ee3c t\u1ed5ng h\u1ee3p v\u1edbi s\u1ed1 l\u01b0\u1ee3ng l\u1edbn c\u00f9ng m\u1ed9t l\u00fac b\u1eb1ng ph\u01b0\u01a1ng ph\u00e1p khu\u00f4n m\u1eabu mu\u1ed1i v\u00e0 \u1ee9c ch\u1ebf hi\u1ec7u qu\u1ea3 s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a ung th\u01b0 v\u00fa trong c\u00e1c th\u00ed nghi\u1ec7m trong c\u01a1 th\u1ec3 s\u1ed1ng v\u00e0 trong \u1ed1ng nghi\u1ec7m, cho th\u1ea5y ti\u1ec1m n\u0103ng c\u1ee7a BNNS trong c\u00e1c \u1ee9ng d\u1ee5ng v\u1eadn chuy\u1ec3n thu\u1ed1c. M\u1ed9t s\u1ed1 nghi\u00ean c\u1ee9u \u0111\u00e3 ph\u00e1t hi\u1ec7n ra r\u1eb1ng khi s\u1eed d\u1ee5ng BN h\u00ecnh c\u1ea7u l\u00e0m ch\u1ea5t mang, peptide l\u1ee3i natri n\u00e3o ch\u1ee9a axit deoxyribonucleic s\u1ebd th\u00e2m nh\u1eadp v\u00e0o t\u1ebf b\u00e0o IAR-6-1 c\u00f3 kh\u1ed1i u th\u00f4ng qua con \u0111\u01b0\u1eddng n\u1ed9i b\u00e0o, sau \u0111\u00f3 gi\u1ea3i ph\u00f3ng DOX v\u00e0o t\u1ebf b\u00e0o ch\u1ea5t v\u00e0 nh\u00e2n, do \u0111\u00f3 nh\u1eafm m\u1ee5c ti\u00eau v\u00e0 ti\u00eau di\u1ec7t t\u1ebf b\u00e0o ung th\u01b0.<\/p>\n

(3) K\u1ef9 thu\u1eadt m\u00f4<\/p>\n

Trong l\u0129nh v\u1ef1c v\u1eadt li\u1ec7u nha khoa, BNN \u0111\u01b0\u1ee3c ch\u1ebf t\u1ea1o b\u1eb1ng ph\u01b0\u01a1ng ph\u00e1p nghi\u1ec1n bi n\u0103ng l\u01b0\u1ee3ng cao v\u00e0 ph\u00e2n t\u00e1n trong ma tr\u1eadn zirconia, v\u00e0 b\u1ed9t t\u1ed5ng h\u1ee3p \u0111\u01b0\u1ee3c h\u1ee3p nh\u1ea5t b\u1eb1ng ph\u01b0\u01a1ng ph\u00e1p thi\u00eau k\u1ebft plasma. Zirconia c\u00f3 th\u00eam BNN cho th\u1ea5y \u0111\u1ed9 b\u1ec1n l\u00ean t\u1edbi 27,3% v\u00e0 \u0111\u1ed9 d\u1ebbo dai khi g\u00e3y l\u00e0 37,5%, \u0111\u1ed3ng th\u1eddi \u1ee9c ch\u1ebf s\u1ef1 ph\u00e2n h\u1ee7y c\u1ee7a ma tr\u1eadn zirconia trong m\u00f4i tr\u01b0\u1eddng \u1ea9m \u01b0\u1edbt, ch\u1ee9ng minh gi\u00e1 tr\u1ecb ti\u1ec1m n\u0103ng c\u1ee7a BNN nh\u01b0 m\u1ed9t ch\u1ea5t gia c\u1ed1 v\u1eadt li\u1ec7u nha khoa.<\/p>\n

(4) Ch\u1ea5t ph\u00e2n ph\u1ed1i Bo<\/p>\n

Do h\u00e0m l\u01b0\u1ee3ng bo cao v\u00e0 \u0111\u1ed9c t\u00ednh t\u1ebf b\u00e0o th\u1ea5p, v\u1eadt li\u1ec7u nano nitride Bo c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng l\u00e0m ch\u1ea5t ph\u00e2n ph\u1ed1i bo cho li\u1ec7u ph\u00e1p b\u1eaft gi\u1eef neutron bo (BNCT). BNCT l\u00e0 m\u1ed9t lo\u1ea1i \u0111i\u1ec1u tr\u1ecb ung th\u01b0 b\u1eb1ng b\u1ee9c x\u1ea1 \u0111\u1eb7c hi\u1ec7u m\u1edbi c\u00f3 th\u1ec3 nh\u1eafm m\u1ee5c ti\u00eau v\u00e0 ti\u00eau di\u1ec7t c\u00e1c t\u1ebf b\u00e0o ung th\u01b0 m\u00e0 kh\u00f4ng g\u00e2y h\u1ea1i cho c\u00e1c t\u1ebf b\u00e0o b\u00ecnh th\u01b0\u1eddng. C\u00e1c \u1ed1ng nano nitride boron \u0111\u01b0\u1ee3c bi\u1ebfn \u0111\u1ed5i b\u1eb1ng polyethylene glycol \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh l\u00e0 t\u00e1c nh\u00e2n cung c\u1ea5p boron cho BNCT. S\u1ef1 t\u00edch t\u1ee5 boron trong c\u00e1c t\u1ebf b\u00e0o u h\u1eafc t\u1ed1 B16 cao g\u1ea5p kho\u1ea3ng ba l\u1ea7n so v\u1edbi t\u00e1c nh\u00e2n cung c\u1ea5p boron th\u1ebf h\u1ec7 th\u1ee9 hai BSH (dinatri thiododecaborane). C\u00e1c \u1ed1ng nano nitride boron \u0111\u01b0\u1ee3c bi\u1ebfn \u0111\u1ed5i b\u1eb1ng polylysine v\u00e0 axit folic \u0111\u01b0\u1ee3c c\u00e1c t\u1ebf b\u00e0o \u0111a d\u1ea1ng glioblastoma h\u1ea5p th\u1ee5 m\u1ed9t c\u00e1ch ch\u1ecdn l\u1ecdc sau khi k\u1ebft h\u1ee3p v\u1edbi c\u00e1c ch\u1ea5m l\u01b0\u1ee3ng t\u1eed hu\u1ef3nh quang. Ch\u00fang kh\u00f4ng ch\u1ec9 c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng l\u00e0m t\u00e1c nh\u00e2n cung c\u1ea5p boron cho BNCT m\u00e0 c\u00f2n c\u00f3 th\u1ec3 theo d\u00f5i h\u00e0nh vi n\u1ed9i b\u00e0o c\u1ee7a thu\u1ed1c. C\u00e1c h\u1ea1t nano nitride boron c\u0169ng \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o l\u00e0 m\u1ed9t kho ch\u1ee9a boron ch\u1ea5t l\u01b0\u1ee3ng cao \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb ung th\u01b0 tuy\u1ebfn ti\u1ec1n li\u1ec7t. Nitrua boron v\u1edbi \u0111\u1ed9 k\u1ebft tinh c\u00f3 th\u1ec3 ki\u1ec3m so\u00e1t c\u00f3 th\u1ec3 li\u00ean t\u1ee5c gi\u1ea3i ph\u00f3ng boron, do \u0111\u00f3 l\u00e0m gi\u1ea3m ho\u1ea1t \u0111\u1ed9ng c\u1ee7a c\u00e1c t\u1ebf b\u00e0o ung th\u01b0 tuy\u1ebfn ti\u1ec1n li\u1ec7t v\u00e0 g\u00e2y ra ch\u1ee9ng apoptosis t\u1ebf b\u00e0o. M\u00f4 h\u00ecnh kh\u1ed1i u t\u1ea1i ch\u1ed7 \u0111\u00e3 x\u00e1c nh\u1eadn hi\u1ec7u qu\u1ea3 ch\u1ed1ng ung th\u01b0 trong c\u01a1 th\u1ec3 s\u1ed1ng c\u1ee7a c\u00e1c qu\u1ea3 c\u1ea7u nitride boron r\u1ed7ng.<\/p>\n","protected":false},"excerpt":{"rendered":"

Nitride bo l\u00e0 tinh th\u1ec3 ph\u00e2n t\u1eed nhi\u1ec1u l\u1edbp c\u00f3 c\u1ea5u tr\u00fac m\u1ea1ng l\u1ee5c gi\u00e1c \u0111\u1ec1u bao g\u1ed3m nguy\u00ean t\u1ed1 nh\u00f3m ch\u00ednh th\u1ee9 ba l\u00e0 bo v\u00e0 nguy\u00ean t\u1ed1 nh\u00f3m ch\u00ednh th\u1ee9 n\u0103m l\u00e0 nit\u01a1.<\/p>\n","protected":false},"author":7,"featured_media":134890,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[852],"tags":[],"class_list":["post-134925","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cong-nghiep-tin-tuc-vi"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.alpapowder.com\/vi\/wp-json\/wp\/v2\/posts\/134925","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.alpapowder.com\/vi\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.alpapowder.com\/vi\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.alpapowder.com\/vi\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/www.alpapowder.com\/vi\/wp-json\/wp\/v2\/comments?post=134925"}],"version-history":[{"count":1,"href":"https:\/\/www.alpapowder.com\/vi\/wp-json\/wp\/v2\/posts\/134925\/revisions"}],"predecessor-version":[{"id":134926,"href":"https:\/\/www.alpapowder.com\/vi\/wp-json\/wp\/v2\/posts\/134925\/revisions\/134926"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.alpapowder.com\/vi\/wp-json\/wp\/v2\/media\/134890"}],"wp:attachment":[{"href":"https:\/\/www.alpapowder.com\/vi\/wp-json\/wp\/v2\/media?parent=134925"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.alpapowder.com\/vi\/wp-json\/wp\/v2\/categories?post=134925"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.alpapowder.com\/vi\/wp-json\/wp\/v2\/tags?post=134925"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}